Cesium carbonate → HCID 57860544, compound

Participants

Reaction Steps

In the same manner as in Reference Example 56, ethyl 3-(2,2-difluoroethoxy)-6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate was obtained from the compound of Reference Example 40 (500 mg, 1.31 mmol), 2,2-difluoroethyl trifluoromethanesulfonate (336 mg, 1.57 mmol) and cesium carbonate (554 mg, 1.70 mmol). The title compound (314 mg, 83%) was obtained as a white powder from the thus-obtained ethyl 3-(2,2-difluoroethoxy)-6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (400 mg, 0.90 mmol) by a method similar to that in Reference Example 59.

Provenance & Evidence