Hydrogen chloride-ethyl acetate → HCID 66892814, compound

Participants

Reaction Steps

To a solution of the compound of Example 146 (150 mg, 0.310 mmol) in ethyl acetate (20 mL) was added 4N hydrogen chloride ethyl acetate solution (93.0 μL, 0.372 mmol). The mixture was concentrated under reduced pressure, and the residue was dissolved in ethyl acetate (30 mL) and ethanol (5 mL). Hexane (10 mL) was added, and the mixture was stirred at room temperature for 15 hr. The precipitated solid was collected by filtration, and washed with ethyl acetate to give the title compound (90.0 mg, 56%) as a white solid.

Provenance & Evidence