HCID 59829821, compound → HCID 59829782, compound

Participants

Reaction Steps

Crude crystals of 4-[4-(morpholin-4-ylmethyl)-phenyl]-1-(5-isopropyl-2,4-bismethoxymethoxy-benzoyl)thiosemicarbazide (IM5-S-a02) and 5% aqueous sodium hydroxide (30 mL) were placed in a 100 mL eggplant shaped flask and refluxed for 2 hours. After completing the reaction, the reaction mixture was extracted with methylene chloride, and the organic layer was combined, dried over anhydrous sodium sulfate. After filtration and evaporation, the residue thus obtained was purified by silica gel column chromatography to obtain the title compound (IM6-S-a02: 1.43 g, 41.6%).

Provenance & Evidence