Hydrochloric Acid → HCID 178438840, compound

Participants

Reaction Steps

Crystals of 5-(5-isopropyl-2,4-bis-methoxymethoxy-phenyl)-4-[4-(morpholin-4-ylmethyl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-thione (IM6-S-a02) (1.43 g, 2.77 mmol) and a mixed solvent of 5.0 N aqueous hydrochloric acid (15 mL) and ethanol (15 mL) were placed in a 100 mL eggplant shaped flask and stirred at room temperature for 3.5 hours. After completing the reaction, the reaction mixture was neutralized with 5 N aqueous sodium hydroxide and then extracted with ethyl acetate. After drying over anhydrous sodium sulfate the collected organic layer was concentrated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography to obtain the title compound (SH-a02: 647 mg, 54.7%).

Provenance & Evidence