Sodium Hydroxide → HCID 86683460, compound

Participants

Reaction Steps

4-[4-(morpholin-4-ylmethyl)-phenyl]-1-[5-(but-2-ynyl)-2,4-bismethoxymethoxy-benzoyl]thiosemicarbazide (F461-IM01: 71.3 mg, 0.133 mmol) and 5% aqueous sodium hydroxide (5 mL) were placed in a 30 mL eggplant shaped flask and heated under reflux for 2.5 hours. After completing the reaction, the reaction mixture was extracted with methylene chloride and concentrated under reduced pressure. The crude product (F461-IM02) thus obtained was subjected to the next reaction without purification in particular.

Provenance & Evidence