Sodium Hydroxide → HCID 59829807, compound

Participants

Reaction Steps

The crude crystals of 4-[4-(morpholin-4-yl)-phenyl]-1-(5-bromo-2,4-bis methoxymethoxy-benzoyl)thiosemicarbazide (IM5-S-d01) and 5% aqueous sodium hydroxide (1 mL) were added in a test tube and refluxed for 2 hours. After completing the reaction, the reaction mixture was extracted with methylene chloride, and the combined organic layer was dried over anhydrous sodium sulfate. Filtration and evaporation gave crude crystals of 5-(5-bromo-2,4-bis-methoxymethoxy-phenyl)-4-[4-(morpholin-4-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-thione (IM6-S-d01) (2 steps, 35.6%). These crude crystals were subjected to the next reaction without purification in particular.

Provenance & Evidence