Hydrochloric Acid → HCID 178516578, compound

Participants

Reaction Steps

The crude crystals of 5-(5-bromo-2,4-bis-methoxymethoxy-phenyl)-4-[4-(morpholin-4-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-thione (IM6-S-d01) and a mixed solvent of 5.0 N aqueous hydrochloric acid (1 mL) and ethanol (1 mL) were placed in a test tube and stirred at room temperature for 24 hours. After completing the reaction, the reaction mixture was neutralized with 10 N aqueous sodium hydroxide, and then extracted with ethyl acetate and methylene chloride. The collected organic layer was dried over anhydrous sodium sulfate. After filtration and evaporation, the residue thus obtained was purified by HPLC fractionation to obtain the title compound (SH-d01: 8.6 mg, 34%).

Provenance & Evidence