反应详情

4-methoxyphenyl-1-[5-isopropyl-2,4-bis(methoxymethoxy)-benzoyl]thiosemicarbazide (F53-03: 24.9 g, 53.7 mmol) and 5% aqueous sodium hydroxide (500 mL) were placed in a 1 L eggplant shaped flask and heated under reflux for 1 hour. After completing the reaction, the reaction mixture was neutralized with saturated aqueous ammonium chloride, and the solids deposited were collected by filtration, washed with distilled water and then dried under reduced pressure. The crude product thus obtained was purified by suspending in ethyl acetate/hexane and concentrating under reduced pressure to obtain the title compound (F53-04:20.5 g, 85.4%).

1. temperatureheated
2. temperatureunder reflux for 1 hour
3. customthe reaction
4. filtrationthe solids deposited were collected by filtration
5. washwashed with distilled water
6. customdried under reduced pressure
7. customThe crude product thus obtained
8. customwas purified
9. concentrationconcentrating under reduced pressure