Hydrazine → HCID 178439251, compound

HRID 1947194Notes

Reaction equation

HRID 1947194 reaction equation
[CH2:1]([O:8][C:9]1[CH:29]=[C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:27]([CH:38]([CH3:40])[CH3:39])=[CH:26][C:10]=1[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[CH:16][CH:15]=1)=S)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:41][NH2:42]>C(O)C>[CH2:1]([O:8][C:9]1[CH:29]=[C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:27]([CH:38]([CH3:40])[CH3:39])=[CH:26][C:10]=1[C:11](=[N:41][NH2:42])[NH:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[CH:16][CH:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 59829893HCID 59829893, compound

Product 1

HCID 178439251HCID 178439251, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,4-bis-benzyloxy-5-isopropyl-N-[4-(morpholin-4-yl)-phenyl]thiobenzamide (F370-IM3; crude product, 4.2 g) was suspended in ethanol (30 mL), mixed with 80% aqueous hydrazine solution (15 mL) and heated under reflux for 4 hours. At this time, it was observed that the suspension was decolored and became a homogeneous solution. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue thus obtained (crude F370-IM4) was used for the next reaction without purification.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customthe residue thus obtained (crude F370-IM4)
  5. customwas used for the next reaction without purification

Sources & evidence

ORD record
ord-87720abbf467481983739d48f81d6e74
Source dataset
uspto-grants-2013_03
Patent number
US08399464B2

Reaction notes

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