反应详情

2,4-bis-benzyloxy-5-isopropyl-N-[4-(morpholin-4-yl)-phenyl]thiobenzamide (F370-IM3; crude product, 4.2 g) was suspended in ethanol (30 mL), mixed with 80% aqueous hydrazine solution (15 mL) and heated under reflux for 4 hours. At this time, it was observed that the suspension was decolored and became a homogeneous solution. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and the residue thus obtained (crude F370-IM4) was used for the next reaction without purification.

1. temperatureheated
2. temperatureunder reflux for 4 hours
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. customthe residue thus obtained (crude F370-IM4)
5. customwas used for the next reaction without purification