Potassium Carbonate → HCID 178438833, compound

Participants

Reaction Steps

A methanol solution of 5-(5-isopropyl-2,4-bis-allyloxy-phenyl)-4-[4-(morpholin-4-ylmethyl)-phenyl]-4H-[1,2,4]triazol-3-ol (37.9 mg, 0.077 mmol) was mixed with tetrakis(triphenylphosphine) palladium (7 mg, 0.007 mmol) and potassium carbonate (64 mg, 0.46 mmol) and reacted at 80° C. for 12 hours. The residue obtained after the concentration was purified by silica gel column chromatography (dichloromethane:methanol 15:1-10:1) to obtain the title compound (OH-a02: white solid, 4.5 mg, 14%).

Provenance & Evidence