Sodium Hydroxide → HCID 59829805, compound

Participants

Reaction Conditions

Reaction Steps

At room temperature aqueous sodium hydroxide (1.0 M aqueous solution, 7 mL) was added to a dimethylsulfoxide solution (7 mL) of the crude product (1.01 g), which was obtained in the previous step, containing 3-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-4-(4-molpholin-4-ylmethylphenyl)-5-methanesulfonyl-4H-[1,2,4]triazole (F45-05). The reaction mixture was heated at 90° C. for 5.5 hours while stirring, cooled to room temperature, extracted with ethyl acetate, and the extract was washed twice with water and then saturated sodium chloride solution. The extract was dried over anhydrous sodium sulfate, and then sodium sulfate was removed by filtration. The solvent was distilled off under reduced pressure to obtain a pale yellow foam. Reprecipitation purification was carried out (chloroform, diethyl ether), and the solids were washed with diethyl ether and dried under reduced pressure to obtain 5-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-4-(4-morpholin-4-ylmethylphenyl)-2,4-dihydro-[1,2,4]triazole-3-one (F45-06, pale yellow solid, 469 mg, 53%).

Provenance & Evidence