Sodium Carbonate → HCID 59829873, compound

Participants

Reaction Steps

2,4-bis-allyloxy-5 (but-2-ynyl)-N-[4-(morpholin-4-ylmethyl)-phenyl]-benzamide (F470-IM09: 400 mg, 0.86 mmol) and Lawesson's reagent (352 mg, 0.86 mmol) were dissolved in toluene (20 mL), and the mixture was heated under reflux for 3 hours. The reaction mixture was mixed with saturated aqueous sodium carbonate (30 mL) and extracted twice with ethyl acetate (40 mL). The combined organic layers were washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and then concentrated. The residue was purified by silica gel column chromatography (ethyl acetate) to obtain the crude title compound (F470-IM10:240 mg).

Provenance & Evidence