Tetrahydrofuran → HCID 59829889, compound

Participants

Reaction Steps

Crude 2,4-bis-allyloxy-5 (but-2-ynyl)-N-[4-(morpholin-4-yl)-phenyl]-benzene-carbohydrazonamide (F470-IM11: 243 mg) was dissolved in anhydrous tetrahydrofuran (5 mL) and mixed with 1,1′-carbonyldiimidazole (121 mg, 0.75 mmol), and the mixture was stirred for 1.5 hours. The reaction mixture was mixed with saturated sodium carbonate solution (15 mL) and extracted twice with ethyl acetate (30 mL). The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and then concentrated to obtain the crude title compound (F470-IM12: 208 mg).

Provenance & Evidence