Hydrochloric Acid → HCID 135407816, compound

Participants

Reaction Steps

Under a nitrogen atmosphere crude 5-[2,4-bis-allyloxy-5-(but-2-ynyl)-phenyl]-4-[4-(morpholin-4-ylmethyl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one(F470-IM12: 208 mg) was dissolved in methanol (10 mL) and mixed with potassium carbonate (348 mg, 2.52 mmol) and tetrakis (triphenylphosphine) palladium (20 mg, 0.016 mmol), and the mixture was heated for 3 hours under reflux. After adding water (5 mL), the reaction mixture was adjusted to pH 6.5 with 2M hydrochloric acid. Silica gel (2.0 g) was added to this mixture and the mixture was concentrated. The residue was purified by silica gel column chromatography (chloroform-methanol=30:1-10:1) to obtain the title compound (OH-c02: 38 mg, yield 10.4%, in 4 steps).

Provenance & Evidence