Potassium Sulfite → HCID 59829843, compound

Participants

Reaction Conditions

Reaction Steps

3-(5-isopropyl-2,4-bis-methoxymethoxy-phenyl)-4-(4-methoxy-phenyl)-5-methylsulfanyl-4H-[1,2,4]triazole (F60-01: 2.87 g, 6.3 mmol) and methylene chloride (60 mL) were placed in a 200 mL eggplant shaped flask, cooled to 0° C., and methylene chloride solution of metachloroperbenzoic acid (3.77 g, 21.9 mmol) was gradually added in 4 portions, and the mixture was stirred for 9.5 hours. After completing the reaction, 10% aqueous potassium sulfite (100 mL) was added and stirring was continued for 10 minutes. After that, the organic layer was extracted, washed twice with 1 N sodium hydroxide (50 mL), dried with sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (F60-02: 2.67 g, 87%)

Provenance & Evidence