Sodium Thiosulfate → HCID 59829848, compound

Participants

Reaction Steps

While stirring in ice cold conditions, 3-chloroperbenzoic acid (4.20 g, 24.4 mmol) was added to a methylene chloride (10 mL) solution of 4-isopropyl-3-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-5-methylsulfanyl-4H-[1,2,4]triazole (F63-04, 1.93 g, 4.87 mmol). After stirring at room temperature for 2 hours, the mixture was bring back to ice cold conditions again, and saturated aqueous sodium thiosulfate and then saturated aqueous sodium hydrogencarbonate were added. After stirring for a while, the reaction mixture was extracted with ethyl acetate, and the extract was washed with saturated sodium chloride solution. After drying the extract over anhydrous sodium, sodium sulfate was removed by filtration and the solvent was distilled off under reduced pressure to obtain a pale yellow foam. After purification by silica gel column chromatography (hexane, ethyl acetate), 4-isopropyl-3-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-5-methylsulfonyl-4H-[1,2,4]triazole (F63-05, colorless foam, 1.65 g, 79%) was obtained.

Provenance & Evidence