Dimethyl Sulfoxide → HCID 59829809, compound

Participants

Reaction Conditions

Reaction Steps

At room temperature, aqueous sodium hydroxide (1.0 M aqueous solution, 9 mL) was added to a dimethylsulfoxide (11 mL) solution of 4-isopropyl-3-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-5-methyl sulfonyl-4H-[1,2,4]triazole (F63-05, 1.63 g, 3.82 mmol). The mixture was heated at 90-100° C. for 12 hours while stirring. After returning to room temperature, water was added. The reaction mixture was extracted with ethyl acetate, and the extract was washed twice with water and then with saturated sodium chloride solution. After drying the extract over anhydrous sodium, sodium sulfate was removed by filtration and the solvent was distilled off under reduced pressure to obtain white solids. After suspension purification by diethyl ether, the solids obtained by filtration were dried under reduced pressure to obtain 4-isopropyl-5-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-2,4-dihydro-[1,2,4]triazol-3-one (F63-06, white solids, 1.09 g, 78%).

Provenance & Evidence