Dichloromethane → HCID 136159955, compound

Participants

Reaction Steps

5-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-4-piperidin-1-yl-2,4-dihydro-[1,2,4]triazol-3-thione (F67-05: 92 mg, 0.18 mmol), methylene chloride (2 mL) and a methylene chloride solution of boron trichloride (1 mol/L, 1 mL) were placed in a test tube and stirred at room temperature for 1 hour. After completing the reaction, methanol and sodium hydrogencarbonate were added to the reaction mixture and solids were separated by filtration. The mother liquor thus obtained was concentrated under reduced pressure and the residue was purified by HPLC fractionation to obtain the title compound (OH-a24 trifluoroacetate, 9.5 mg, 16.6%).

Provenance & Evidence