Hydrochloric Acid → HCID 136159996, compound

Participants

Reaction Steps

5 N hydrochloric acid (0.5 mL) was added to a methanol solution (0.5 mL) of 4-isopropyl-3-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-5-methylsulfonyl-4H-[1,2,4]triazole (an intermediate of Example 2-13 F63-05: 35 mg, 82 μmol) and the mixture was stirred for 8 hours. After cooling to ice cold conditions, it was neutralized by adding saturated aqueous sodium hydrogencarbonate. The solution was extracted with ethyl acetate, and the extract was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and then sodium sulfate was removed by filtration and the solvent was distilled off under reduced pressure. The solids thus obtained were dried under reduced pressure to obtain 4-isopropyl-6-(4-isopropyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)-benzene-1,3-diol (SFN-a21, white solids, 20.8 mg, 75%).

Provenance & Evidence