Sodium Chloride → HCID 59829785, compound

Participants

Reaction Conditions

Reaction Steps

5-(5-isopropyl-2,4-bis-methoxymethoxy-phenyl)-4-isopropyl-2,4-dihydro-[1,2,4]triazol-3-thione (F63-03: 114 mg, 0.3 mmol), potassium carbonate (249 mg, 1.8 mmol) and ethanol (10 mL) were placed in a test tube, and next 3-dimethylaminopropyl chloride hydrochloride (1.49 g, 9.4 mmol) was added. The mixture was stirred at 100° C. for 1 hour. After completing the reaction, the reaction mixture was cooled naturally, mixed with saturated sodium chloride solution and extracted twice with ethyl acetate. The organic layers were combined, washed 4 times with saturated sodium chloride solution, then dried with sodium sulfate and concentrated under reduced pressure.

Provenance & Evidence