2-Methylthiopyrimidine-4,6-diamine → Ethyl 4-amino-5-(4-cyano-2-methoxyphenyl)-7-methyl-2-(methylthio)-5,8-dihydropyrido[2,3-d]-pyrimidine-6-carboxylate

Participants

Reaction Steps

740 mg (2.70 mmol) of ethyl 2-(4-cyano-2-methoxybenzylidene)-3-oxobutanoate and 422 mg (2.70 mmol) of 2-(methylthio)pyrimidine-4,6-diamine are dissolved in 5 ml of isopropanol and heated under reflux under argon for 12 h. The mixture is filtered and the remaining solid is washed with isopropanol. 395 mg (35% of theory) of the title compound are obtained as a white solid.

Provenance & Evidence