4-Iodobenzaldehyde → HCID 178500496, compound

HRID 1947260Notes

Reaction equation

Cl.Cl.[CH:3]1([NH:9][C:10]2[C:14]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[N:13]([CH2:20][CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])[C:12](=[O:27])[N:11]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[I:28][C:29]1[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=1>>[CH:3]1([NH:9][C:10]2[C:14]3([CH2:19][CH2:18][N:17]([CH2:33][C:32]4[CH:35]=[CH:36][C:29]([I:28])=[CH:30][CH:31]=4)[CH2:16][CH2:15]3)[N:13]([CH2:20][CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])[C:12](=[O:27])[N:11]=2)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

Reactant 2

HCID 966574-Iodobenzaldehyde

HCID 178500498HCID 178500498, compound

Product 1

HCID 178500496HCID 178500496, compound

Procedure

Reductive amination using methyl 4-[4-(cyclohexylamino)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-1-yl]butanoate dihydrochloride and 4-iodo-benzaldehyde using a similar procedure as described in the preparation of intermediate I.1.d.1. LRMS (M+1)=567.5.

Workup

customas described in the preparation of intermediate I.1.d.1

Sources & evidence

ORD record: ord-0ce7ae1dcdde410e8fda1f6d669a9f53
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399473B2

Reaction notes

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