Methanol → HCID 149433996, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-cyano-4-[(4-iodophenyl)amino]piperidine-1-carboxylate (22 g, 51.5 mmol) in DCM (150 mL) was added trichloroacetylisocyanate (6.12 mL, 51.5 mmol) dropwise. After stirring at rt for 1 h30, triethylamine (7.18 mL, 51.5 mmol), water (4.64 mL, 257.5 mmol) and methanol (10.43 mL, 257.5 mmol), and the reaction mixture was stirred at 40° C. for 3 h, cooled to rt, diluted with water (200 mL), and a purple solid was filtered on paper, washed with water and a small amount of DCM, and air dried to afford the desired product as a white solid. LRMS (M+1)=471.

Provenance & Evidence