Sodium Iodide → HCID 11959535, compound

Participants

Reaction Steps

A 3 L flask was charged with 4-piperidinone hydrate (10.4 g, 60.8 mmol), K2CO3 (45 g, 326 mmol), acetonitrile (2000 mL) and NaI (0.49 g, 3.3 mmol). To the mixture while stirring was added 4-iodobenzyl bromide (17.5 g, 58.8 mmol). The mixture was stirred at rt overnight, filtered over a coarse glass frit and the filtrate concentrated to give 25 g crude. Recrystallization from hot EtOAc in hexanes gave 11 g (53%) of a clean crop as orange crystals: LRMS (M+1)=316.

Provenance & Evidence