Dimethylamine → HCID 58235079, compound

HRID 1947293Notes

Reaction equation

HRID 1947293 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:9]([C:11]2[CH:12]=[C:13]([C:28](O)=[O:29])[CH:14]=[C:15]3[C:20]=2[O:19][C:18]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[CH:17][C:16]3=[O:27])[CH3:10])=[CH:4][CH:3]=1.[CH3:31][NH:32][CH3:33]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][CH:9]([C:11]2[CH:12]=[C:13]([C:28]([N:32]([CH3:33])[CH3:31])=[O:29])[CH:14]=[C:15]3[C:20]=2[O:19][C:18]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)=[CH:17][C:16]3=[O:27])[CH3:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 58235003HCID 58235003, compound

Product 1

HCID 58235079HCID 58235079, compoundYield 60.7%

Procedure

8-(1-(4-fluorophenylamino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (82 mg, 0.20 mmol) was reacted with dimethylamine (0.119 mL, 0.24 mmol) using a procedure similar to the one described in Example 2.00 to afford 8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (53 mg, 60.7%) as a white solid. Mass Spectrum: M+H+ 440.

Sources & evidence

ORD record
ord-428d7b314f194b83bd0043dbdde0e3a3
Source dataset
uspto-grants-2013_03
Patent number
US08399460B2

Reaction notes

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