Hydrochloric Acid → 2-{4'-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1'-biphenyl-4-yl}pyridazin-3(2H)-one HCl

Participants

Reaction Steps

2-{4′-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1-biphenyl-4-yl}pyridazin-3(2H)-one (226 mg) was suspended in methanol (4.0 mL). A solution of 1 M HCl in methanol (0.66 mL) was added to the suspension dropwise. Throughout the process the suspension is stirred using a magnetic stirrer. Most of the solid dissolved leaving a light suspension. Upon sonication, crystallization was observed. The resulting suspension was agitated at ambient temperatures overnight before the crystals were harvested.

Provenance & Evidence