Dichloromethane → 2-{4'-[(3Ar,6ar)-5-methylhexahydropyrrolo[3,4-b]pyrrol-1(2h)-yl]-1,1'-biphenyl-4-yl}pyridazin-3(2h)-one l-tartrate salt monohydrate

Participants

Reaction Conditions

Reaction Steps

2-{4′-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1′-biphenyl-4-yl}pyridazin-3(2H)-one tartrate (Form A) was suspended in 1 mL of solution mixture, which was prepared by mixing 3.0 mL of dichloromethane with 1.5 mL of 20% water (in methanol). The suspension was vortexed and heated in a shaking water bath to about 40° C. and maintained for 1.5 hrs. It was further heated to about 70° C. The suspension was then filtered. The water bath was turned off, and the supernatant cooled to ambient temperatures naturally in the water bath. Single crystals were offered.

Provenance & Evidence