HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 24993819, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Reactant | 2-Amino-5-cyanopyridine | HCID 818260 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 24993819 | HCID 24993819 | 46.1% |
Reaction Steps
2-Bromo-1-(4-fluoro-phenyl)-ethanone (2.08 g, 9.6 mmol) and 6-amino-nicotinonitrile (1.14 g, 9.6 mmol) were heated under reflux in 50 ml dioxane for 13 hours. After cooling the solid was filtered and purified by preparative HPLC (RP18, acetonitrile/water 0.1% TFA) to yield 1.05 g (46%) of the desired product. MS: M+H+=238.04.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399476B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f9a877c728794ff1b31e4c33edaa5865 |
| Source note | uspto-grants-2013_03 |