Triethylamine → HCID 178473664, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-Fluoro-phenyl)-N-hydroxy-imidazo[1,2-a]pyridine-6-carboxamidine (example 56; 85.1 mg, 0.315 mmol) was dissolved in 5 ml DMF. The mixture was heated to 80° C. after addition of triethylamine (87.8 μl, 0.63 mmol) and ethyl chloroformate (33 μl, 0.34 mmol) for 2.5 hours. The mixture was evaporated. Ethyl acetate and water were added, the organic layer was separated, washed with water, dried and evaporated. The crude product was purified by preparative HPLC (RP18, acetonitrile/water 0.1% TFA) to yield 48 mg (45%) of the desired product. MS: M+H+=343.05.

Provenance & Evidence