反应详情

To a solution of 6-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.18 g, 0.9 mmol) in MeCN (9 mL) was added Cs2CO3 (0.6 g, 1.8 mmol), 2-chloro-thiazolo[4,5-b]pyridine hydrochloride (0.18 g, 0.9 mmol) and the reaction mixture was stirred (rt, 3 h). The reaction mixture was filtered and concentrated in vacuum to provide the title compound as pink solid (0.18 g, 60%). MS (ESI): mass calcd. for C11H10N2O3S2, 342.0; m/z found, 343.0 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.58 (dd, J=4.8, 1.6, 1H), 8.12-8.00 (m, 3H), 7.92 (d, J=8.8, 1H), 7.46 (dd, J=8.8, 2.2, 1H), 7.24-7.18 (m, 1H), 3.96 (s, 3H).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated in vacuum