Thionyl Chloride → HCID 86647609, compound

Participants

Reaction Steps

A mixture of 5-(thiazolo[4,5-b]pyridin-2-yloxy)-benzofuran-2-carboxylic acid (326 mg, 1.04 mmol) and thionyl chloride (10 mL) was heated to reflux for 2 h. The crude mixture was concentrated, re-dissolved in CH2Cl2 and concentrated again to provide the product as a yellow solid (375 mg, 98%). 1H NMR (400 MHz, DMSO-d6): 8.61-8.51 (m, 2H), 7.97 (d, J=2.5, 1H), 7.94-7.86 (m, 1H), 7.74 (s, 1H), 7.68-7.61 (m, 1H), 7.46-7.38 (m, 1H).

Provenance & Evidence