Hydrochloric Acid → HCID 68769983, compound

Participants

Reaction Steps

To a solution of 4-[6-(thiazolo[4,5-b]pyridin-2-yloxy)-benzofuran-3-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester (0.22 g, 0.47 mmol) in DCM (5 mL) is added HCl (4 M in dioxane, 1 mL, 8.5 equiv.) and the solution was stirred (rt, 1 h). The reaction mixture was concentrated in vacuo to provide the desired product as a white solid (0.25 g, 129%). [Note: the mass recovery of 129% was attributed to additional HCl that could not be removed by standard evaporation under reduced pressure]. MS (ESI): mass calcd. for C19H18N4O2S, 366.44; m/z found, 367.1 [M+H]+.

Provenance & Evidence