Lithium Hydroxide → HCID 66786516, compound

Participants

Reaction Steps

To a solution of 3-{methyl-[6-(thiazolo[4,5-b]pyridin-2-yloxy)-benzofuran-3-ylmethyl]-amino}-propionic acid ethyl ester (30 mg, 0.07 mmol) in THF (0.75 mL) was added 4 N LiOH (0.1 mL). The mixture was stirred (rt, 6.5 h). Purification by reverse phase HPLC provided the title compound as a white solid (7 mg, 21%). MS (ESI): mass calcd. for C19H17N3O4S, 383.09; m/z found, 384.9 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.49 (dd, J=4.9, 1.6, 1H), 8.32 (dd, J=8.0, 1.6, 1H), 8.15 (s, 1H), 7.97-7.92 (m, 1H), 7.80 (d, J=2.1, 1H), 7.44 (dd, J=8.6, 2.1, 1H), 7.38-7.32 (m, 1H), 4.48 (s, 2H), 3.35 (t, J=6.5, 2H), 2.80 (s, 3H), 2.66 (t, J=6.5, 2H).

Provenance & Evidence