Triethylamine → HCID 68769927, compound

Participants

Reaction Steps

To a solution of 6-(thiazolo[4,5-b]pyridin-2-yloxy)-benzofuran-3-carbonyl chloride hydrochloride (256 mg, 0.77 mmol) in CH2Cl2 (7.7 mL) was added Et3N (0.32 mL, 2.32 mmol) and methylamine dihydrochloride (81 mg, 0.77 mmol). The reaction mixture was stirred (rt, 1 h). Water followed by sat'd. aq. NaHCO3 was added to the mixture. The resultant precipitate was filtered and concentrated to provide the title compound (115 mg, 45%). MS (ESI): mass calcd. for C16H11N3O3S, 325.05; m/z found, 326.0 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.57 (dd, J=4.8, 1.6, 1H), 8.23 (s, 1H), 8.17-8.01 (m, 2H), 7.37 (dd, J=8.6, 2.2, 1H), 7.24 (dd, J=7.9, 4.8, 1H), 7.01 (d, J=26.5, 1H), 3.00 (d, J=4.8, 3H).

Provenance & Evidence