HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → Methyl 2-methyl-2-(4-nitrophenoxy)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-bromo-2-methylpropionate | HCID 90097 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-methyl-2-(4-nitrophenoxy)propanoate | HCID 57562956 | — |
Reaction Steps
A heterogeneous mixture of 4-nitrophenol (5 g), methyl 2-bromoisobutyrate (5.6 mL) and K2CO3 (7.5 g) in acetone (60 mL) was refluxed overnight. The reaction mixture was then diluted with water (150 mL) and extracted with ethyl acetate (2×100 mL). The organic layers were evaporated to give methyl 2-(4-nitrophenoxy)isobutyrate (49).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399472B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-23e54914dfe64cf69f9211eb367b17e9 |
| Source note | uspto-grants-2013_03 |