Pyridine → HCID 49834169, compound

Participants

Reaction Steps

To a stirred solution of 7-benzylamino-3,4-dihydro-2H-isoquinolin-1-one (100 mg, 0.34 mmol) and pyridine (63 μl, 0.77 mmol) in anhydrous dichloromethane (2 ml) was added 1-methyl-1H-pyrazole-3-sulfonyl chloride (138 mg, 0.77 mmol) and the reaction heated at reflux for 15 hrs. The reaction was cooled and the solvent evaporated in vacuo. The crude residue was purified by flash column chromatography (50% ethyl acetate in dichloromethane) to afford the title compound as a colourless solid (63 mg, 41%). HPLC retention time 4.16 min. Mass spectrum (ES+) m/z 431 (M+H).

Provenance & Evidence