Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | HCID 24960700 | HCID 24960700 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 24958504 | HCID 24958504 | — |
Reaction Steps
tert-Butyl 1′-(4-iodophenyl)-4,4′-bipiperidine-1-carboxylate (17 mg, 0.036 mmol) from Step 1, 1H-1,2,4-triazole (7.5 mg, 0.108 mmol), CuI (0.7 mg, 0.0036 mmol), N,N-dimethylethane-1,2-diamine (1 mg, 0.0072 mmol), K3PO4 (16 mg, 0.0756 mmol) were mixed in a 1 dram vial, followed by addition of DMF (0.1 mL). The reaction vessel was degassed and back-filled with Ar 3 times, before it was heated at 100° C. for 20 hours. The reaction was cooled, diluted with water, extracted with EtOAc, concentrated and purified by PTLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399485B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-fdb3ef54d5e24a89ad0ace2b4113b8b4 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
