HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → HCID 59178969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | HCID 59178818 | HCID 59178818 | — |
| Reactant | HCID 131730302 | HCID 131730302 | — |
| Catalyst | copper(II) trifluoromethanesulfonate | HCID 2734996 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59178969 | HCID 59178969 | — |
Reaction Steps
A solution of tert-butyl 1′-(4-{([(2-hydroxyethyl)amino]carbonyl}phenyl)-4,4′-bipiperidine-1-carboxylate (234 mg; 0.542 mmol) in dioxane (5 mL) was treated with N,N′-diisopropylcarbodiimide (68 mg; 0.084 mmol) and Cu(OTf)2 (10 mg; 0.027 mmol). The mixture was refluxed for 5 hr. The reaction was evaporated and chromatographed (PTLC; 40:1 CH2Cl2/MeOH), giving the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399485B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-6b8f482ff5304057a7a6ca0e8a766c9e |
| Source note | uspto-grants-2013_03 |