HuagongsheHuagongshe Chemistry Print Report · For research reference only
2(5H)-Furanone, 5-hydroxy-4-methyl- → ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2(5H)-Furanone, 5-hydroxy-4-methyl- | HCID 115301 | — |
| Reactant | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate | HCID 77231410 | — |
Reaction Steps
5-Hydroxy-4-methylfuran-2(5H)-one (1.19 g, 10.4 mmol) and ethyl hydrazinoacetate hydrochloride (1.61 g, 10.4 mmol) in 95% ethanol (20 mL) was refluxed for 2 h. Removal of the solvent in vacuo followed by purification using a Biotage Horizon® system (0-50% ethyl acetate/hexanes mixture) gave ethyl [4-methyl-6-oxopyridazin-1(6H)-yl]acetate as a yellow crystalline. LC/MS 219.2 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399480B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-ce6909f73aff4620aa9cbd906c15e233 |
| Source note | uspto-grants-2013_03 |