HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl(3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate | HCID 59011720 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid | HCID 57907519 | 1,012.6% |
Reaction Steps
To a solution of 0.090 g (0.39 mmol) of tert-butyl (3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate from step B above in 4 mL of anhydrous dichloromethane was added 1 mL of TFA. The resulting mixture was stirred at ambient temperature for 6 h then evaporated to dryness in vacuo to afford the title compound as an off-white gum (0.68 g, 99%). LC-MS: m/z (ES) 173 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399480B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d778348c041042b285ca1b3f70600362 |
| Source note | uspto-grants-2013_03 |