HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 6-Amino-7-bromo-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-amino-2,3-dihydro-1H-inden-1-one | HCID 312895 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Amino-7-bromo-2,3-dihydro-1H-inden-1-one | HCID 53422064 | — |
Reaction Steps
A solution of 6-aminoindanone (12 g, 81.6 mmol) in N,N-dimethylformamide (220 ml) is treated with N-bromosuccinimide (14.5 g, 81.6 mmol) in portions over a period of one hour and stirred for one hour. Evaporation of the solvent and water/dichloromethane workup followed by purification by chromatography with EtOAc/hexane (1:3) as eluent gives the product 6-amino-7-bromoindanone; LC/MS: 226/228 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399490B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-081e82fd7d164541803bba57ef91a2d7 |
| Source note | uspto-grants-2013_03 |