Water → HCID 68498064, compound

Participants

Reaction Steps

A solution of 5-chloro-2-hydroxy-6-{[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-indane carboxylic acid isopropylamide (230 mg, 0.35 mmol) in dichloromethane is treated with pyridinium chlorochromate (29 mg, 1.0 mmol), stirred for 10 hours, and treated with water. Organic layer is separated, dried over sodium sulfate, filtered, and evaporated. Purification by chromatography using ethyl acetate/hexane as eluent gives 5-chloro-6-{[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-indan-2-one carboxylic acid isopropylamide as solid; LC/MS: 540/542 (M+1)+; m.p.: 198-199° C.

Provenance & Evidence