反应详情

The dimethyl(3-nitrobenzyl)phosphane oxide (153 mg) produced as described above was hydrogenated in the presence of 10% Pd/C (100 mg) in MeOH (5 mL) overnight. The mixture was filtered and the filtrate concentrated in vacuo to afford 128 mg of the desired 3-[(dimethylphosphoryl)methyl]aniline (yield: 96%), which was used in further chemistries without purification. 1H-NMR (CDCl3, 400 MHz): δ=1.44 (d, J=12.8 Hz, 6H), 3.06 (d, J=15.6 Hz, 2H), 3.81 (s, br, 2H), 6.55-6.58 (m, 3H), 7.08 (t, J=7.6 Hz, 1H). MS (ES+): m/z 184.02 (MH+). HPLC: tR=0.58 and 0.90 min (ZQ3, polar—5 min).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate concentrated in vacuo