Diethyl(4-nitrophenyl)phosphonate → Diethyl (4-aminophenyl)phosphonate

Participants

Reaction Steps

A mixture of diethyl(4-nitrophenyl)phosphonate (150 mg, 0.58 mmol), EtOH (40 ml) and 10% Pd/C (30 mg) was hydrogenated under 50 psi of hydrogen pressure at 40° C. for 6 h. After cooling to room temperature, the reaction mixture was filtered and the filtrate concentrated in vacuo to afford 130 mg of desired diethyl(4-aminophenyl)phosphonate (yield: 98%), which was used directly in further chemistries without purification.

Provenance & Evidence