2-((2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylbenzamide → Diethyl(3-methoxy-4-{[4-{[2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Participants

Reaction Steps

Prepared according to the procedure described for Example 48 using (2-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}-N-methylbenzamide and diethyl(4-amino-3-methoxybenzyl)phosphonate. 1H NMR (CD3OD, 400 MHz): δ=1.27 (t, J=7.07 Hz, 6H), 2.90 (s, 3H), 3.20-3.28 (m, 2H), 3.91 (s, 3H), 4.01-4.11 (m, 4H), 6.80 (dt, J=8.21, 2.21 Hz, 1H), 6.99 (t, J=2.15 Hz, 1H), 7.19 (td, J=7.58, 1.26 Hz, 1H), 7.48 (ddd, J=8.46, 7.20, 1.52 Hz, 1H), 7.64 (dd, J=7.83, 1.52 Hz, 1H), 7.96 (d, J=8.08 Hz, 1H), 8.30-8.36 (m, 2H). MS (ES+): m/z 568.1542 [MH+] (TOF, polar).

Provenance & Evidence