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HRID1947833

反应详情

EQUATION

反应方程式

HRID 1947833 的结构方程式

REACTANTS

反应物

2
结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC
HCID86654002

未命名化合物

结构：CN1Cc2c(c(N)ccc2[C@H]2CC[C@H](O)CC2)C1=O
HCID178479967

未命名化合物

PRODUCTS

生成物

1
结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc([C@H]4CC[C@H](O)CC4)c4c3C(=O)N(C)C4)n2)cc1)OCC
HCID178476862

未命名化合物

PROCEDURE

实验过程

This compound was prepared in a manner analogous to Example 87 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-4-(trans-4-hydroxycyclohexyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one. Purification: ISCO Combi-flash Rf system, eluting with 0 to 5% MeOH in EtOAc. 1H NMR (400 MHz, DMSO-d6) δ 10.57 (s, 1H), 9.87 (s, 1H), 8.45 (s, 1H), 7.56 (br. s., 1H), 7.38 (d, J=8.59 Hz, 1H), 7.26 (dd, J=2.15, 8.46 Hz, 2H), 4.58 (d, J=4.55 Hz, 1H), 4.52 (s, 2H), 3.91-4.01 (m, 4H), 3.46-3.54 (m, 1H), 3.17-3.27 (m, 2H), 3.08 (s, 3H), 1.94 (d, J=9.85 Hz, 2H), 1.76 (d, J=12.13 Hz, 2H), 1.53-1.65 (m, 2H), 1.23-1.36 (m, 2H), 1.18 (t, J=7.07 Hz, 6H). MS (ES+): m/z: 648.1830 [MH+]. HPLC: tR=1.44 min (UPLC TOF MS: polar—3 min).

WORKUP

后处理

  1. customPurification
  2. washISCO Combi-flash Rf system, eluting with 0 to 5% MeOH in EtOAc
  3. customHPLC: tR=1.44 min (UPLC TOF MS: polar—3 min)