HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione → Diethyl[3-methoxy-4-({4-[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione | HCID 600596 | — |
| Reactant | Diethyl (4-{[4-chloro-5-(trifluoromethyl) pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate | HCID 86654002 | — |
| Product | Diethyl[3-methoxy-4-({4-[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate | HCID 49821190 | — |
Reaction Steps
The title compound was prepared using the procedure for Example 102 with diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and the commercially available 4-amino-2-methyl-1H-isoindole-1,3(2H)-dione. MS (ES+): m/z 594.34 (100) [MH+]; HPLC: tR=1.17 min (UPLC, purity).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-30dc4253bcb3428dadc56e0a349a24ea |
| Source note | uspto-grants-2013_03 |