2-Amino-N,N-dimethylbenzamide → Diethyl (4-{[4-{[2-(dimethylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

HRID 1947871Notes

Reaction equation

HRID 1947871 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][CH:14]=2)[N:3]=1.[NH2:28][C:29]1[CH:39]=[CH:38][CH:37]=[CH:36][C:30]=1[C:31]([N:33]([CH3:35])[CH3:34])=[O:32]>>[CH3:34][N:33]([CH3:35])[C:31]([C:30]1[CH:36]=[CH:37][CH:38]=[CH:39][C:29]=1[NH:28][C:2]1[C:7]([C:8]([F:10])([F:11])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][CH:14]=2)[N:3]=1)=[O:32]

Participants

3

Reactant 2

HCID 47781752-Amino-N,N-dimethylbenzamideHCID 86654003Diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Product 1

HCID 49821269Diethyl (4-{[4-{[2-(dimethylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Procedure

The title compound was prepared using the procedure for Example 102 with diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate and the commercially available 2-amino-N,N-dimethylbenzamide. MS (ES+): m/z 552.38 (100) [MH+]; HPLC: tR=0.96 min (UPLC, purity).

Sources & evidence

ORD record
ord-a3ff0ba2fed841a1b5388e794775813a
Source dataset
uspto-grants-2013_03
Patent number
US08399433B2

Reaction notes

Loading…