HRID1947890

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67254279

未命名化合物

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Cl)n2)c(OC)c1)OCC

HCID86654002

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(C(=O)O)c4c3C(=O)N(C)C4)n2)c(OC)c1)OCC

HCID58293005

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the procedure from Example 102 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and Compound 128A. MS (ES+): m/z 624.19 (100) [MH+]; HPLC: tR=1.07 min (UPLC, purity).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5651090d45ac4235a62348129c4b6ffa
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08399433B2
来源说明: uspto-grants-2013_03

反应 SMILES

Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=[C:4]([NH:12][C:13]2[CH:27]=[CH:26][C:16]([CH2:17][P:18](=[O:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[CH:15][C:14]=2[O:28][CH3:29])[N:3]=1.[NH2:30][C:31]1[C:39]2[C:38](=[O:40])[N:37]([CH3:41])[CH2:36][C:35]=2[C:34]([C:42]([OH:44])=[O:43])=[CH:33][CH:32]=1>>[CH2:20]([O:19][P:18]([CH2:17][C:16]1[CH:26]=[CH:27][C:13]([NH:12][C:4]2[N:3]=[C:2]([NH:30][C:31]3[C:39]4[C:38](=[O:40])[N:37]([CH3:41])[CH2:36][C:35]=4[C:34]([C:42]([OH:44])=[O:43])=[CH:33][CH:32]=3)[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:5]=2)=[C:14]([O:28][CH3:29])[CH:15]=1)([O:22][CH2:23][CH3:24])=[O:25])[CH3:21]