HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-fluoro-N-methylbenzamide → Diethyl (4-amino-3-fluoro-5-methoxybenzyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-fluoro-N-methylbenzamide | HCID 43132558 | — |
| Reactant | Diethyl (3-fluoro-5-methoxy-4-nitrobenzyl)phosphonate | HCID 86654023 | — |
| Product | Diethyl (4-amino-3-fluoro-5-methoxybenzyl)phosphonate | HCID 86654022 | — |
Reaction Steps
The title compound was prepared using the procedure from Compound 102A (2-Amino-5-fluoro-N-methylbenzamide) with Diethyl (3-fluoro-5-methoxy-4-nitrobenzyl)phosphonate (Compound 146B). 1H NMR (CDCl3, 400 MHz): δ=1.27 (t, J=7.07 Hz, 6H), 2.99-3.08 (m, 2H), 3.87 (s, 3H), 4.00-4.06 (m, 4H), 6.59 (s, 1H), 6.63 (dt, J=10.74, 2.21 Hz, 1H). MS (ES+): m/z 292.06 [MH+] (TOF, polar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399433B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-cbd200dc5be84042aef7b6a1f4681a45 |
| Source note | uspto-grants-2013_03 |